Formulation And Performance Evaluation Of Betahistine Dihydrochloride Microspheres As Sustained Release Systems
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چکیده
منابع مشابه
Formulation and performance evaluation of betahistine dihydrochloride microspheres as sustained release systems.
UNLABELLED Betahistine dihydrochloride is a histamine-like drug widely used in relieving the symptoms associated with Ménière's syndrome. Pharmacokinetic studies of betahistine have demonstrated that it has a short plasma half-life of 3-4 hours. In such cases frequent administration of the drug is required in order to keep plasma concentration within the therapeutic range. However, this may lea...
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In order to reduce dosing frequency, a sustained release dosage form of betahistine dihydrochloride was developed as a twice daily controlled release tablet formulation that could be used to decrease vertigo resulted in Meniere's disease for a prolonged time. Six formulations were developed by using Methocel K4M CR, Methocel K15M CR and Methocel K 100 LVCR as single and combinations in differen...
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ژورنال
عنوان ژورنال: Folia Medica
سال: 2014
ISSN: 1314-2143
DOI: 10.2478/folmed-2014-0027